Simon Wolfe of Capsule Computers writes:
"Blood+ was a popular anime series during its run from 2005 to 2006, coming from a movie and leading to another albeit live-action movie. So, what better way to capitalize on the success of the name then to make another series, which is exactly what some might find with Blood-C, a (maybe?) sequel series to the original. Can Blood-C capture the audience like the series before it? Does it build upon the story or go in a new direction? With any luck it's still the same old Saya we all love."