Just take a second to picture this situation. You are teenage boy with a deep obsession with zombies, you wish to have a zombie girlfriend. One day the most popular girl from a all girls high school becomes a zombie, it becomes your job to ensure her safety and survival. What would you think? What would you do? Well apart from thinking what the hell is going on, or doing things that should not be done, you would general try to do whats right and Sankarea follows the main character as he is faced with these questions.